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Review
. 2009 Jan;10(1):59-68.
doi: 10.2217/14622416.10.1.59.

EGFR-targeted therapies in lung cancer: predictors of response and toxicity

Rebecca Suk Heist  1 , David Christiani
Affiliations
Review

EGFR-targeted therapies in lung cancer: predictors of response and toxicity

Rebecca Suk Heist et al. Pharmacogenomics. 2009 Jan.

Abstract

The EGFR pathway has emerged as a key target in non-small-cell lung cancer. EGF receptor (EGFR) inhibition in non-small-cell lung cancer is achieved via small molecular tyrosine kinase inhibitors, such as erlotinib or gefitinib, or monoclonal antibodies such as cetuximab. A growing body of evidence is identifying potential molecular predictors of response and toxicity. This includes tumor-related molecular markers, such as EGFR mutation and copy number, as well as germline markers such as polymorphisms in EGFR or EGFR pathway-related genes. This review focuses on the current state of knowledge of predictors of response and toxicity to EGFR inhibitors in lung cancer.

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Figures

Figure 1
Figure 1. Mechanisms of action of anti-EGFR drugs
Inhibition of cancer cell proliferation and invasion, metastatsis and tumor-induced neoangiogenesis. Induction of cancer cell cycle arrest and potentiation of antitumor activity of cytotoxic drugs and radiotherapy. Reproduced with permission from [2].
See this image and copyright information in PMC

References

    1. Jorissen RN, Walker F, Pouliot N, Garrett TPJ, Ward CW, Burgess AW. Epidermal growth factor receptor: mechanisms of activation and signaling. Exp. Cell Res. 2003;284:31–53. - PubMed

    1. Ciardiello F, Tortora G. EGFR antagonists in cancer treatment. N. Engl. J. Med. 2008;358:1160–1174. Excellent review article encompassing clinical use of EGF receptor (EGFR) inhibitors in oncology.

    1. Sheperd FA, Pereira JR, Ciuleanu T, et al. Erlotinib in previously treated non-small cell lung cancer. N. Engl. J. Med. 2005;353:123–132. Pivotal Phase III trial showing benefit of EGFR tyrosine kinase inhibitor (TKI) erlotinib in lung cancer.

    1. Fukuoka M, Yano S, Giaccone G, et al. Multi-institutional randomized Phase II trial of gefitinib for previously treated patients with advanced non-small cell lung cancer. J. Clin. Oncol. 2003;21:2237–2246. - PubMed
    1. Kris MG, Natale RB, Herbst RS, et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor tyrosine kinase, in symptomatic patients with non-small cell lung cancer. JAMA. 2003;290:2149–2158. - PubMed

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