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. 2008 Dec 23;14(1):36-45.
doi: 10.3390/molecules14010036.

Caffeic acid derivatives from Eupatorium perfoliatum L

Mareike Maas  1 , Frank Petereit, Andreas Hensel
Affiliations

Caffeic acid derivatives from Eupatorium perfoliatum L

Mareike Maas et al. Molecules. .

Abstract

From the ethyl acetate soluble fraction of a methanol/water extract of the herb Eupatorium perfoliatum L. (Asteraceae) six caffeic acid derivatives have been isolated and identified by 1D- and 2D-NMR spectroscopic data. Besides the common quinic acid derivatives 5-caffeoylquinic acid (chlorogenic acid), 3-caffeoylquinic acid (neochlorogenic acid) and 3,5-dicaffeoylquinic acid, three up to now unknown depsides of caffeic acid with glucaric acid have been isolated: 2,5-dicaffeoylglucaric acid, 3,4-dicaffeoylglucaric acid, and 2,4- or 3,5-dicaffeoylglucaric acid.

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Figures

Figure 1
Figure 1
RP-HPLC chromatogram of the ethyl acetate fraction obtained from a partition of a MeOH/water extract from E. perfoliatum; detection wavelength 325 nm. Peaks C1 to C8 correspond to caffeic acid derivatives, peaks F1 to F4 correspond to flavonoids.
Figure 2
Figure 2
Structure of dicaffeoylglucaric acid derivatives C3, C4 and C5 from E. perfoliatum.
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