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. 2008 Dec 23;14(1):46-52.
doi: 10.3390/molecules14010046.

Structure-activity relationship of flavonoids active against lard oil oxidation based on quantum chemical analysis

Ji-Guo Yang  1 , Ben-Guo Liu, Gui-Zhao Liang, Zheng-Xiang Ning
Affiliations

Structure-activity relationship of flavonoids active against lard oil oxidation based on quantum chemical analysis

Ji-Guo Yang et al. Molecules. .

Abstract

In this study, the antioxidant activities of 15 flavonoids against lard oil oxidation were determined by using the Rancimat test. Quercetin, dihydromyricetin, luteolin and kaempferol showed the strongest antioxidant activity, with protection factor values (PF) of 11.50, 11.29, 4.24 and 2.49, respectively. The role of conjugated hydroxyl groups of the B and C ring is discussed. By using the following descriptors: DeltaH(f) (the difference in heat of formation between flavonoids and their free radicals resulted after hydrogen atom donation) and H(BC) (the number of conjugated hydroxyl groups of the B and C ring), the result obtained in the antioxidant Rancimat test could be successfully explained.

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Figures

Figure 1
Figure 1
Antioxidant activity of luteolin, dihydromyricetin, quercetin and TBHQ in the Rancimat test.
See this image and copyright information in PMC

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