Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Jan-Feb;11(1):3-13.
doi: 10.1021/cc800183m.

Distributed Drug Discovery, Part 1: linking academia and combinatorial chemistry to find drug leads for developing world diseases

William L Scott  1 , Martin J O'Donnell
Affiliations

Distributed Drug Discovery, Part 1: linking academia and combinatorial chemistry to find drug leads for developing world diseases

William L Scott et al. J Comb Chem. 2009 Jan-Feb.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Diagram of distributed problem solving at three stages of Distributed Drug Discovery.
Figure 2
Figure 2
Role of D3-based virtual catalogs in integrating computational analysis with synthesis.
Figure 3
Figure 3
Globally accessible databases of D3 target molecules.
Scheme 1
Scheme 1. Role of Resin-Bound Amino Acids 1 as a Key Combinatorial Intermediate
Scheme 2
Scheme 2. Preparation of an Acylated Unnatural Amino Acid (5) Library,
Figure 4
Figure 4
Bill-Board equipment for Distributed Drug Discovery.
Figure 5
Figure 5
Generic structure 6, anti-melanoma lead 7, and analogs 8 accessible through D3.
Figure 6
Figure 6
Generic Structures for the First Virtual D3 Catalogs.
See this image and copyright information in PMC

References

    1. Disease Analysis/Prevalence:

    2. The World Health Report 2004: Changing History.http://www.who.int/whr/2004/en/ (accessed November 2, 2008).

    3. The World Health Report 2005: Make Every Mother and Child Count. http://www.who.int/whr/2005/en/ (accessed November 2, 2008).

    4. The World Health Report 2006: Working Together for Health. http://www.who.int/whr/2006/en/ (accessed November 2, 2008).

    5. Mathers C. D.; Loncar D. PLoS Med. 2006, 3, 2011–2030. - PMC - PubMed

    6. The World Health Report 2007: A Safer Future: Global Public Health Security in the 21st Century. http://www.who.int/whr/2007/en/ (accessed November 2, 2008).

    7. World Malaria Report 2008. http://www.who.int/malaria/wmr2008/ (accessed November 2, 2008).

    8. The World Health Report 2008: Primary Health Care—Now More Than Ever. http://www.who.int/whr/2008/en/index.html (accessed November 2, 2008).

    1. Focusing Attention on Developing World Diseases:

    2. Varmus H.; Klausner R.; Zerhouni E.; Acharya T.; Daar A. S.; Singer P. A. Science 2003, 302, 398–399. - PMC - PubMed
    3. Yach D.; Hawkes C.; Gould C. L.; Hofman K. J. J. Am. Med. Assoc. 2004, 291, 2616–2622. - PubMed
    4. Birn A.-E. Lancet 2005, 366, 514–519. - PubMed
    5. Morel C. M.; Acharya T.; Broun D.; Dangi A.; Elias C.; Ganguly N. K.; Gardner C. A.; Gupta R. K.; Haycock J.; Heher A. D.; Hotez P. J.; Kettler H. E.; Keusch G. T.; Krattiger A. F.; Kreutz F. T.; Lall S.; Lee K.; Mahoney R.; Martinez-Palomo A.; Mashelkar R. A.; Matlin S. A.; Mzimba M.; Oehler J.; Ridley R. G.; Senanayake P.; Singer P.; Yun M. Science 2005, 309, 401–404. - PubMed
    6. Nwaka S.; Hudson A. Nat. Rev. Drug Discovery 2006, 5, 941–955. - PubMed
    7. Omenn G. S. Science 2006, 314, 1696–1704.
    8. O’Connell D. Nature 2007, 449, 157.
    9. Butler D. Nature 2007, 449, 158–159. - PubMed
    10. Callan B.; Gillespie I. Nature 2007, 449, 164–165. - PubMed
    11. Hopkins A. L.; Witty M. J.; Nwaka S. Nature 2007, 449, 166–169. - PubMed
    12. Yamada T. Nat. Rev. Drug Discovery 2007, 6, 950. - PubMed
    13. McNeil D. G.,. Jr. Jump-Start on Slow Trek to Treatment for a Disease. The New York Times, January 8, 2008, pp D5−D7

    14. Open-Access Public Library of Science (PloS) Journal PloS Neglected Tropical Diseases. http://www.plosntds.org/home.action (accessed November 2, 2008

    1. The concept of “Distributed Drug Discovery” was first presented by WLS at a seminar at the Department of Biochemistry, Biophysics and Biotechnology at the Jagiellonian University in Kraków, Poland on April 7, 2003.

    1. See first article following this Perspective:

    2. Scott W. L.; Alsina J.; Audu C. O.; Babaev E.; Cook L.; Dage J. L.; Goodwin L. A.; Martynow J. G.; Matosiuk D.; Royo M.; Smith J. G.; Strong A. T.; Wickizer K.; Woerly E. M.; Zhou Z.; O’Donnell M. J. J. Comb. Chem. 2009, 11, 14–33. - PMC - PubMed
    1. See second article following this Perspective:Scott W. L.; Audu C. O.; Dage J. L.; Goodwin L. A.; Martynow J. G.; Platt L. K.; Smith J. G.; Strong A. T.; Wickizer K.; Woerly E. M.; O’Donnell M. J. J. Comb. Chem. 2009, 11, 34–43. - PMC - PubMed

Publication types

MeSH terms