Review
doi: 10.1016/0952-7915(91)90031-u.
T-cell-mediated cytotoxicity
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- PMID: 1910610
- DOI: 10.1016/0952-7915(91)90031-u
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Review
T-cell-mediated cytotoxicity
Curr Opin Immunol.
1991 Jun.
Abstract
There are two competing theories to explain the mechanism(s) by which cytolytic T lymphocytes kill target cells: granule exocytosis of a pore-forming protein, and contact-induced internal disintegration. Accumulated evidence supports alternative pathways in lymphocytoxicity, possibly reflecting distinct effector functions expressed by different killer cells and cells at different stages of activation.
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