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. 2009 May-Jun;21(3):389-91.
doi: 10.1002/ajhb.20858.

Adiponectin and type 2 diabetes in Samoan adults

Julia R Dibello  1 , Ana Baylin, Satupaitea Viali, John Tuitele, Linda Bausserman, Stephen T McGarvey
Affiliations

Adiponectin and type 2 diabetes in Samoan adults

Julia R Dibello et al. Am J Hum Biol. 2009 May-Jun.

Abstract

Objective: Previous studies have established an association between adiponectin and type 2 diabetes. It is unclear whether adiponectin will be useful among Samoan Islanders, characterized by markedly elevated levels of obesity, in differentiating those at risk of developing type 2 diabetes.

Methods: Cross-sectional, genetic epidemiology study of obesity in American Samoa and Samoa 2002-2003 (n = 1,599). Logistic regression provided adjusted odds ratios and 95% confidence intervals for the association between adiponectin, diabetes, and prediabetes (impaired fasting glucose).

Results: There is a significant decreasing trend in the odds of diabetes and prediabetes across increasing quintiles of adiponectin with an OR of 2.8 (95% CI: 1.6, 5.0) and 2.9 (95% CI: 1.5, 5.7), respectively, in the lowest relative to the highest quintile of adiponectin (P-for-trend = 0.004 and 0.001).

Conclusions: Adiponectin is an important correlate, independent of other risk factors, of the pathogenesis of type 2 diabetes among Samoan islanders and may help distinguish those at higher risk of developing this disease.

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