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. 2009 Feb;5(2):91-3.
doi: 10.1038/nchembio.134. Epub 2008 Dec 21.

Sialic acid dependence in rotavirus host cell invasion

Thomas Haselhorst  1 , Fiona E Fleming, Jeffrey C Dyason, Regan D Hartnell, Xing Yu, Gavan Holloway, Kim Santegoets, Milton J Kiefel, Helen Blanchard, Barbara S Coulson, Mark von Itzstein
Affiliations

Sialic acid dependence in rotavirus host cell invasion

Thomas Haselhorst et al. Nat Chem Biol. 2009 Feb.

Abstract

We used NMR spectroscopy, molecular modeling and infectivity competition assays to investigate the key interactions between the spike protein (VP8(*)) from 'sialidase-insensitive' human Wa and 'sialidase-sensitive' porcine CRW-8 rotaviruses and the glycans of gangliosides G(M1) and G(D1a). Our data provide strong evidence that N-acetylneuraminic acid is a key determinant for binding of these rotaviruses. This is in contrast to the widely accepted paradigm that sialic acids are irrelevant in host cell recognition by sialidase-insensitive rotaviruses.

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References

    1. J Virol. 2008 Jul;82(13):6139-49 - PubMed
    1. J Mol Biol. 2007 Apr 6;367(4):1215-26 - PubMed
    1. Nat Rev Microbiol. 2007 Jul;5(7):529-39 - PubMed
    1. Glycobiology. 2007 Jan;17(1):68-81 - PubMed
    1. Glycoconj J. 2006 Feb;23(1-2):27-37 - PubMed

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