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. 2008:52.
doi: 10.3402/fnr.v52i0.1641. Epub 2008 Jan 18.

Effect of peptides derived from food proteins on blood pressure: a meta-analysis of randomized controlled trials

Are Hugo Pripp  1
Affiliations

Effect of peptides derived from food proteins on blood pressure: a meta-analysis of randomized controlled trials

Are Hugo Pripp. Food Nutr Res. 2008.

Abstract

Background: In clinical trials, peptides derived from food proteins have shown an effect on blood pressure. This biological mechanism is mainly due to inhibition of angiotensin-I-converting enzyme (ACE), thereby regulating blood pressure through the renin-angiotensin system. A meta-analysis of these trials is needed to better quantify their effect, sources of variation, and possible publication bias.

Objective: To perform a meta-analysis of placebo-controlled clinical trials on peptides derived from food proteins and their effect on blood pressure.

Design: Trials identified using a defined search strategy in PubMed were included in the meta-analysis, and their pooled effect was estimated with a random effects model.

Results: Pooled effect of peptides was -5.13 mmHg (95% CI: -7.12, -3.14) for systolic blood pressure, and -2.42 mmHg (95% CI: -3.82, -1.03) for diastolic blood pressure. There were indications of publication bias for diastolic blood pressure data.

Conclusions: Peptides derived from food proteins may lead to significantly reduced blood pressure and could therefore be a supplement or alternative to pharmaceutical treatment for mild hypertension. Their effect seems more pronounced, or at least comparable, to that of other food components studied by randomized controlled trials. A high proportion of the reported trials was carried out using the well-known ACE inhibiting tripeptides - Valine-Proline-Proline (VPP) and Isoleucine-Proline-Proline (IPP).

Keywords: angiotensin-I-converting enzyme (ACE); clinical trials; hypertension.

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Figures

Fig 1.
Fig 1.
Selection of randomized placebo-controlled trials for meta-analysis.
Fig 2.
Fig 2.
Standard forest plot from meta-analysis on systolic blood pressure. Cochran's Q-test for homogeneity was Q=30.52, p-value = 0.02.
Fig 3.
Fig 3.
Standard forest plot from meta-analysis on diastolic blood pressure. Cochran's Q-test for homogeneity was Q=29.10, p-value = 0.08.
Fig 4.
Fig 4.
Funnel plots of mean effects on systolic and diastolic blood pressure to detect signs of publication bias.
See this image and copyright information in PMC

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