The long and short of membrane fission
- PMID: 19109885
- DOI: 10.1016/j.cell.2008.12.003
The long and short of membrane fission
Abstract
During membrane fission, the GTPase dynamin forms helical assemblies at the neck of membrane buds. Although it has been proposed that fission results from the constriction of the dynamin helix, new work by Bashkirov et al. (2008) and Pucadyil and Schmid (2008) unexpectedly shows that helix disassembly is also necessary for membrane fission.
Comment on
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Real-time visualization of dynamin-catalyzed membrane fission and vesicle release.Cell. 2008 Dec 26;135(7):1263-75. doi: 10.1016/j.cell.2008.11.020. Epub 2008 Dec 11. Cell. 2008. PMID: 19084268 Free PMC article.
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GTPase cycle of dynamin is coupled to membrane squeeze and release, leading to spontaneous fission.Cell. 2008 Dec 26;135(7):1276-86. doi: 10.1016/j.cell.2008.11.028. Epub 2008 Dec 11. Cell. 2008. PMID: 19084269 Free PMC article.
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