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Comparative Study
. 2009 Apr;154(4):498-503.e2.
doi: 10.1016/j.jpeds.2008.10.044. Epub 2008 Dec 25.

Maternal age, multiple birth, and extremely low birth weight infants

Betty R Vohr  1 , Jon E Tyson, Linda L Wright, Rebecca L Perritt, Lei Li, W Kenneth Poole; NICHD Neonatal Research Network
Collaborators, Affiliations
Comparative Study

Maternal age, multiple birth, and extremely low birth weight infants

Betty R Vohr et al. J Pediatr. 2009 Apr.

Abstract

Objectives: To compare the rates of adverse neurodevelopmental outcome or death at 18 to 22 months among extremely low birth weight (ELBW) infants born to mothers >or=4 0 years to the corresponding rates among infants of younger mothers.

Study design: Prospective evaluation of ELBW infants to quantify the relative risks of maternal age and multiple birth for death or adverse neurodevelopmental outcome.

Results: The sample consisted of 14 671 live ELBW births divided into maternal age groups: <20, 20 to 29, 30 to 39, and >or= 40 years. Of infants born to mothers >or= 40 years, 20% were multiples. Mothers >or= 40 years had high rates of obstetric interventions and medical morbidities compared with mothers <40 years. ELBW live births of mothers >or= 40 years were 22% more likely to survive and had a 13% decreased risk of neurodevelopmental impairment or death compared with mothers <20. Multiple birth, however, was associated with a 10% greater risk of neurodevelopmental impairment or death.

Conclusion: Although mothers >or= 40 years had high pregnancy-related morbidities, we found no overall increased risk of the composite outcome of death or NDI. Multiple birth, however, was a predictor of all adverse outcomes examined, regardless of maternal age.

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References

    1. Martin JA, Kochanek KD, Strobino DM, Guyer B, MacDorman MF. Annual summary of vital statistics--2003. Pediatrics. 2005 Mar;115:619–634. - PubMed
    1. Hamilton BE, Martin JA, Ventura SJ, Sutton PD, Menacker F. Births: preliminary data for 2004. Natl Vital Stat Rep. 2005 Dec 29;54:1–17. - PubMed
    1. Hamilton BE, Minino AM, Martin JA, Kochanek KD, Strobino DM, Guyer B. Annual summary of vital statistics: 2005. Pediatrics. 2007 Feb;119:345–360. - PubMed
    1. Heck KE, Schoendorf KC, Ventura SJ, Kiely JL. Delayed childbearing by education level in the United States, 1969–1994. Matern Child Health J. 1997 Jun;1:81–88. - PubMed
    1. Bobrowski RA, Bottoms SF. Underappreciated risks of the elderly multipara. Am J Obstet Gynecol. 1995 Jun;172:1764–1767. discussion 7–70. - PubMed

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