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Comment
. 2009 Jan 6;15(1):3-5.
doi: 10.1016/j.ccr.2008.12.011.

Tumor-associated fibroblasts as "Trojan Horse" mediators of resistance to anti-VEGF therapy

Giulio Francia  1 , Urban Emmenegger, Robert S Kerbel
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Tumor-associated fibroblasts as "Trojan Horse" mediators of resistance to anti-VEGF therapy

Giulio Francia et al. Cancer Cell. .
Free article

Abstract

While targeting VEGF has shown success against a number of human cancers, drug resistance has resulted in compromised clinical benefits. In this issue of Cancer Cell, Crawford et al. (2009) report that tumors resistant to anti-VEGF therapy stimulate tumor-associated fibroblasts to express proangiogenic PDGF-C, implicating it as a potential therapeutic target.

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