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Comment
. 2009 Jan 6;15(1):5-6.
doi: 10.1016/j.ccr.2008.12.008.

Unholy matrimony: Aurora A and N-Myc as malignant partners in neuroblastoma

John M Maris  1
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Unholy matrimony: Aurora A and N-Myc as malignant partners in neuroblastoma

John M Maris. Cancer Cell. .
Free article

Abstract

Aurora A is a mitotic kinase that is essential for regulation of the G2/M checkpoint. In this issue of Cancer Cell, Otto et al. report that Aurora A interacts with MYCN, a potent oncogene in human neuroblastoma, and sequesters it from proteolytic degradation. This surprising finding further enhances Aurora A's potential as a therapeutic target.

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