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. 2009 Mar;30(3):578-80.
doi: 10.3174/ajnr.A1402. Epub 2008 Dec 26.

Fully-automated quantification of regional brain volumes for improved detection of focal atrophy in Alzheimer disease

J B Brewer  1 , S Magda, C Airriess, M E Smith
Affiliations

Fully-automated quantification of regional brain volumes for improved detection of focal atrophy in Alzheimer disease

J B Brewer et al. AJNR Am J Neuroradiol. 2009 Mar.

Abstract

Volumetric analysis of structural MR images of the brain may provide quantitative evidence of neurodegeneration and help identify patients at risk for rapid clinical deterioration. This note describes tests of a fully automated MR imaging postprocessing system for volumetric analysis of structures (such as the hippocampus) known to be affected in early Alzheimer disease (AD). The system yielded results that correlated highly with independent computer-aided manual segmentation and were sensitive to the anatomic atrophy characteristic of mild AD.

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Figures

Fig 1.
Fig 1.
Example coronal sections from automatically segmented MR images from a healthy brain (left) and a patient with AD (right). Arrows indicate medial temporal lobe structures. Colors indicate segmented structures as listed in the Table.
See this image and copyright information in PMC

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