[The extracytoplasmic protein quality control in bacterium Escherichia coli; the role of proteases and the folding factors]

Abstract

The proper functioning of extracytoplasmic proteins requires their correct folding after translocation and reaching a proper destination within the cellular envelope. This process is supervised by the folding factors and proteases, which comprise the protein quality control system. The coordinated action of its components maintains the proper functioning of the cell under physiological conditions and enables the survival of bacteria under stress conditions. In the present work we provide the concise characteristics of the protein quality control system within the cellular envelope with the particular emphasize on the role of proteolysis in maintaining the cellular homeostasis.