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. 2009 Apr;32(4):606-11.
doi: 10.2337/dc08-1869. Epub 2008 Dec 29.

Progression to impaired glucose regulation and diabetes in the population-based Inter99 study

Susanne Engberg  1 , Dorte Vistisen, Cathrine Lau, Charlotte Glümer, Torben Jørgensen, Oluf Pedersen, Knut Borch-Johnsen
Affiliations

Progression to impaired glucose regulation and diabetes in the population-based Inter99 study

Susanne Engberg et al. Diabetes Care. 2009 Apr.

Erratum in

  • Diabetes Care. 2009 Sep;32(9):1751

Abstract

Objective: The purpose of this study was to estimate the progression rates to impaired glucose regulation (impaired fasting glucose or impaired glucose tolerance) and diabetes in the Danish population-based Inter99 study and in a high-risk subpopulation, separately.

Research design and methods: From a population-based primary prevention study, the Inter99 study, 4,615 individuals without diabetes at baseline and with relevant follow-up data were divided into a low- and a high-risk group based on a risk estimate of ischemic heart disease or the presence of risk factors (smoking, hypertension, hypercholesterolemia, obesity, or impaired glucose tolerance). High-risk individuals (57.1%) were examined with an oral glucose tolerance test at 1 and 3 years, and all of the participants were reexamined at the 5-year follow-up. Person-years at risk were calculated. Progression rates to impaired glucose regulation and diabetes were estimated directly from baseline to the 5-year follow-up for all the participants and from baseline through the 1- and 3- to 5-year follow-up examinations for the high-risk individuals, separately.

Results: In the combined low- and high-risk group, 2.1 individuals per 100 person-years progressed from normal glucose tolerance (NGT) to impaired glucose regulation or diabetes. Among high-risk individuals, 5.8 per 100 person-years with NGT progressed to impaired glucose regulation or diabetes, and 4.9 per 100 person-years progressed from impaired glucose regulation to diabetes.

Conclusions: Progression rates to impaired glucose regulation using the current World Health Organization classification criteria were calculated for the first time in a large European population-based study. The progression rates to diabetes show the same pattern as seen in the few similar European studies.

Trial registration: ClinicalTrials.gov NCT00289237.

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References

    1. Edelstein SL, Knowler WC, Bain RP, Andres R, Barrett-Connor EL, Dowse GK, Haffner SM, Pettitt DJ, Sorkin JD, Muller DC, Collins VR, Hamman RF: Predictors of progression from impaired glucose tolerance to NIDDM: an analysis of six prospective studies. Diabetes 46: 701– 710, 1997 - PMC - PubMed
    1. Schranz AG: Abnormal glucose tolerance in the Maltese: a population-based longitudinal study of the natural history of NIDDM and IGT in Malta. Diabetes Res Clin Pract 7: 7– 16, 1989 - PubMed
    1. Skarfors ET, Selinus KI, Lithell HO: Risk factors for developing non-insulin dependent diabetes: a 10 year follow up of men in Uppsala. BMJ 303: 755– 760, 1991 - PMC - PubMed
    1. Njølstad I, Arnesen E, Lund-Larsen PG: Sex differences in risk factors for clinical diabetes mellitus in a general population: a 12-year follow-up of the Finnmark study. Am J Epidemiol 147: 49– 58, 1998 - PubMed
    1. Qiao Q, Lindström J, Valle TT, Tuomilehto J: Progression to clinically diagnosed and treated diabetes from impaired glucose tolerance and impaired fasting glycaemia. Diabet Med 20: 1027– 1033, 2003 - PubMed

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