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. 2009 May;20(5):1175-80.
doi: 10.1007/s10856-008-3646-4. Epub 2008 Dec 30.

Evaluation of a multi-layer microbraided polylactic acid fiber-reinforced conduit for peripheral nerve regeneration

Ming-Chin Lu  1 , Yen-Ting Huang, Jia-Horng Lin, Chun-Hsu Yao, Ching-Wen Lou, Chin-Chuan Tsai, Yueh-Sheng Chen
Affiliations

Evaluation of a multi-layer microbraided polylactic acid fiber-reinforced conduit for peripheral nerve regeneration

Ming-Chin Lu et al. J Mater Sci Mater Med. 2009 May.

Abstract

We evaluated peripheral nerve regeneration using a biodegradable multi-layer microbraided polylactic acid (PLA) fiber-reinforced conduit. Biodegradability of the PLA conduit and its effectiveness as a guidance channel were examined as it was used to repair a 10 mm gap in the rat sciatic nerve. As a result, tube fragmentation was not obvious and successful regeneration through the gap occurred in all the conduits at 8 weeks after operation. These results indicate the superiority of the PLA materials and suggest that the multi-layer microbraided PLA fiber-reinforced conduits provide a promising tool for neuro-regeneration.

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