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. 2009 Jan;72(1):136-41.
doi: 10.1021/np800511r.

Isolation, structure elucidation, and biological activity of virgineone from Lachnum Wirgineum using the genome-wide Candida albicans fitness test

John Ondeyka  1 , Guy Harris, Deborah Zink, Angela Basilio, Francisca Vicente, Gerald Bills, Gonzalo Platas, Javier Collado, Antonio Gonzáez, Mercedes de la Cruz, Jesus Martin, Jennifer Nielsen Kahn, Stefan Galuska, Robert Giacobbe, George Abruzzo, Emily Hickey, Paul Liberator, Bo Jiang, Deming Xu, Terry Roemer, Sheo B Singh
Affiliations

Isolation, structure elucidation, and biological activity of virgineone from Lachnum Wirgineum using the genome-wide Candida albicans fitness test

John Ondeyka et al. J Nat Prod. 2009 Jan.

Abstract

A glycosylated tetramic acid, virgineone (1), was isolated from saprotrophic Lachnum virgineum. The antifungal activity of the fermentation extract of L. virgineum was characterized in the Candida albicans fitness test as distinguishable from other natural products tested. Bioassay-guided fractionation yielded 1, a tyrosine-derived tetramic acid with a C-22 oxygenated chain and a beta-mannose. It displayed broad-spectrum antifungal activity against Candida spp. and Aspergillus fumigatus with a MIC of 4 and 16 microg/mL, respectively. Virgineone was also identified in a number of Lachnum strains collected from diverse geographies and habitats.

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