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. 1977 Jul;60(3):357-62.
doi: 10.1111/j.1476-5381.1977.tb07508.x.

A potent new beta2-adrenoceptor blocking agent

J L Imbs, F Miesch, J Schwartz, J Velly, G Leclerc, A Mann, C G Wermuth

A potent new beta2-adrenoceptor blocking agent

J L Imbs et al. Br J Pharmacol. 1977 Jul.

Abstract

1 (t-Butyl-amino-3-ol-2-propyl) oximino-9 fluorene is a new beta2-adrenoceptor blocking agent with a pA2 of 9.23+/-0.25 on isolated trachea. 2 It provokes hypertension in normotensive rats and does not prevent arterial hypertension in SHR rats, although it does prevent the renin secretion normally induced by isoprenaline infusion.

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References

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