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. 2008 Dec 30;1(1):426.
doi: 10.1186/1757-1626-1-426.

Primary lymphoma of the head and neck: two case reports and review of the literature

Ismail Essadi #  1 , Nabil Ismaili #  2 , Elmehdi Tazi  2 , Sanaa Elmajjaoui  3 , Ammar Saidi  4 , Mohammed Ichou  1 , Hassan Errihani  2
Affiliations

Primary lymphoma of the head and neck: two case reports and review of the literature

Ismail Essadi et al. Cases J. .

Abstract

Background: The head and neck is the second most common region for the extra-nodal lymphomas after that of gastrointestinal tract. Approximately 2.5% of malignant lymphoma arises in the oral and para-oral region. In this paper we report two cases of early stage head and neck lymphoma which were managed successfully with chemotherapy and a review of the related literature.

Cases presentation: The first case concerns a 48 years male patient having a diffuse large B-Cell lymphoma of the oropharynx at early bulky stage. This patient was managed successfully with 7 of Rituximab 375 mg/m2, Cyclophosphamide 750 mg/m2 d1, Doxorubicine 50 mg/m2 d1, Vincristine 1.4 mg/m2 d1, and prednisone 50 mg/m2 d1-5 (RCHOP) regimen. The second case concerns a 50 years female patient having the nasal natural killer (NK)/T-cell lymphoma of the left nasal pit at early stage. This case was managed successfully with 6 of Cyclophosphamide 750 mg/m2 d1, Doxorubicine 50 mg/m2 d1, Vincristine 1.4 mg/m2 d1, and prednisone 50 mg/m2 d1-5 (CHOP) regimen.

Conclusion: These two cases highlight the important role of CHOP based chemotherapy for achieving successful treatment cure for patients having an early stage head and neck lymphoma.

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Figures

Figure 1
Figure 1
Right cervical masse fixed, bulky, measured 13 × 10 cm in diameter.
Figure 2
Figure 2
Computed tomography of the head and neck shows the oropharyngeal process and a bulky cervical mass.
Figure 3
Figure 3
Computed tomography of the head and neck shows the involvement of the nasopharynx by the oropharyngeal process.
Figure 4
Figure 4
The right cervical region was free from the disease 22 month after the end of chemotherapy.
Figure 5
Figure 5
NK/T-cell lymphoma, angiocentric infiltrate of small lymphocytes and atypical cells.
Figure 6
Figure 6
Angiocentric marking by CD 56.
Figure 7
Figure 7
Angiocentric marking by CD 3.
See this image and copyright information in PMC

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