Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Jan;40(1):21-7.
doi: 10.1016/j.injury.2008.09.006. Epub 2008 Dec 30.

The role of erythropoietin in the acute phase of trauma management: evidence today

N K Kanakaris  1 , G Petsatodis, B Chalidis, N Manidakis, G Kontakis, P V Giannoudis
Affiliations
Review

The role of erythropoietin in the acute phase of trauma management: evidence today

N K Kanakaris et al. Injury. 2009 Jan.

Abstract

Trauma patients often present in a state of haemorrhagic shock. Blood products remain the gold standard of resuscitation, but allogeneic blood transfusions (ABTs) are associated with several risks. The stimulating effect of recombinant-erythropoietin (EPO-A) on erythropoiesis has raised interest in its administration as an alternative. The existing evidence on the early use of EPO-A in the acute phase of trauma patients management consists of only 14 publications. The level of evidence of these studies and the number of treated patients was not found to be adequate to support its generalised use, despite their favourable results. Its safety profile, the preliminary proofs of its efficacy, and the additional cyto-protective properties of EPO-A strongly encourage further controlled studies assessing its use in the acute setting of initial trauma management.

PubMed Disclaimer