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Review
. 2009;5(1):20-7.
doi: 10.7150/ijbs.5.20. Epub 2008 Dec 13.

BRCA1, hormone, and tissue-specific tumor suppression

Yanfen Hu  1
Affiliations
Review

BRCA1, hormone, and tissue-specific tumor suppression

Yanfen Hu. Int J Biol Sci. 2009.

Abstract

Germline mutations of BRCA1 predispose women to breast and ovarian cancers. Elucidating molecular mechanism of tissue- and gender-specific phenomena in BRCA1-related tumors is a key to our understanding of BRCA1 function in tumor suppression. This review summarizes studies in recent years on the link between BRCA1 and estrogen/progesterone signaling pathways, as well as discusses various models underscoring a triangle relationship among BRCA1, estrogen and genome instability.

Keywords: BRCA1; estrogen; genome instability.; tumor suppression.

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Conflict of interest statement

Conflict of Interest: The author has declared that no conflict of interest exists.

Figures

Fig 1
Fig 1
The interplay between ERα and BRCA1 pathways and its impact on cell proliferation (1) and genome stability maintenance (2). Solid arrows indicate a direct role while the dashed arrow indicates an indirect pathway (e.g. via a paracrine pathway etc.)
Fig 2
Fig 2
The genomic locations of several tissue-specific promoters of the aromatase gene (CYP 19) and tissue-specific alternative splicing patterns of the aromatase transcripts.
See this image and copyright information in PMC

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