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Comparative Study
. 1991;9(4):317-21.
doi: 10.1016/0731-7085(91)80200-s.

Study of bioequivalence of magnesium and sodium valproates

A Balbi  1 , E Sottofattori, M Mazzei, W G Sannita
Affiliations
Comparative Study

Study of bioequivalence of magnesium and sodium valproates

A Balbi et al. J Pharm Biomed Anal. 1991.

Abstract

The in vivo bioavailability of magnesium valproate (500 and 1000 mg) enteric-coated tablets has been compared with that of sodium valproate (Depakine) (500 and 1000 mg) enteric-coated tablets. The two preparations were found to be bioequivalent; magnesium valproate appeared to be a drug without bioavailability problems and with reduced inter-subject variability, compared with that of sodium valproate. A reversed-phase HPLC method for the determination of valproates is described.

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