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. 2009 Mar;53(3):1275-7.
doi: 10.1128/AAC.01244-08. Epub 2009 Jan 5.

Postantibiotic effects of telavancin against 16 gram-positive organisms

G A Pankuch  1 , P C Appelbaum
Affiliations

Postantibiotic effects of telavancin against 16 gram-positive organisms

G A Pankuch et al. Antimicrob Agents Chemother. 2009 Mar.

Abstract

The in vitro postantibiotic effects (PAEs), postantibiotic sub-MIC effects (PA-SMEs), and sub-MIC effects of telavancin were determined for 16 gram-positive organisms. Telavancin staphylococcal, streptococcal, and enterococcal PAE ranges were 0.9 to 3.9 h, 0.4 to 6.7 h, and 0.3 to 2.2 h, respectively. The PA-SME ranges (0.4 times the MIC) for staphylococci, streptococci, and enterococci were 6.7 to >10.7 h, >10.7 to >11.0 h, and >10 to >10.8 h, respectively. The extended PAE of telavancin, together with its long elimination half-life in humans, supports once-daily dosing for this investigational drug.

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