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. 2009:2009:126917.
doi: 10.1155/2009/126917. Epub 2008 Dec 25.

Characterization of a novel polymorphism in PPARG regulatory region associated with type 2 diabetes and diabetic retinopathy in Italy

Valerio Costa  1 , Amelia Casamassimi, Katherine Esposito, Angela Villani, Mariaelena Capone, Rosa Iannella, Bruno Schisano, Miryam Ciotola, Carmen Di Palo, Feliciantonia Capone Corrado, Franco Santangelo, Dario Giugliano, Alfredo Ciccodicola
Affiliations

Characterization of a novel polymorphism in PPARG regulatory region associated with type 2 diabetes and diabetic retinopathy in Italy

Valerio Costa et al. J Biomed Biotechnol. 2009.

Abstract

Peroxisome proliferator-activated receptor gamma polymorphisms have been widely associated with type 2 diabetes, although their role in the pathogenesis of vascular complications is not yet demonstrated. In this study, a cohort of 211 type 2 diabetes, 205 obese, and 254 control individuals was genotyped for Pro12Ala, C1431T, C-2821T polymorphisms, and for a newly identified polymorphism (A-2819G). The above-mentioned polymorphisms were analyzed by gene-specific PCR and direct sequencing of all samples. A significant difference was found for -2819G frequency when patients with type 2 diabetes-particularly diabetic women with the proliferative retinopathy-were compared with healthy control individuals. In conclusion, we identified a novel polymorphism, A-2819G, in PPARG gene, and we found it to be associated with type 2 diabetes and proliferative retinopathy in diabetic females. In the analyzed population, this variant represents a genetic risk factor for developing the diabetic retinopathy, whereas Pro12Ala and C1431T do not.

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Figures

Figure 1
Figure 1
Comparison of A-2819G frequencies in diabetic women with background or proliferative retinopathy and control women.
See this image and copyright information in PMC

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