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Review
. 1991 Apr;2(2):105-10.

Genetic control of the metastatic phenotype

P S Steeg  1
Affiliations
  • PMID: 1912520
Review

Genetic control of the metastatic phenotype

P S Steeg. Semin Cancer Biol. 1991 Apr.

Abstract

Transfection experiments indicate that a number of genes can induce or suppress the metastatic phenotype. These genes include ten oncogenes, plasminogen activator, and three suppressor genes. The biochemical mechanism(s) whereby each of these genes alters the metastatic phenotype is poorly understood. Hypotheses concerning the coordinate regulation of metastasis-effector genes, and the relationship of gene expression in metastasis to that in embryonic development are discussed.

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