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Review
. 2009 Mar 27;72(3):507-15.
doi: 10.1021/np800568j.

Tubulin-interactive natural products as anticancer agents

David G I Kingston  1
Affiliations
Review

Tubulin-interactive natural products as anticancer agents

David G I Kingston. J Nat Prod. .

Erratum in

  • J Nat Prod. 2011 May 27;74(5):1352

Abstract

This review provides an overview of the discovery, structures, and biological activities of anticancer natural products that act by inhibiting or promoting the assembly of tubulin to microtubules. The emphasis is on providing recent information on those compounds in clinical use or in advanced clinical trials. The vinca alkaloids, the combretastatins, NPI-2358, the halichondrin B analogue eribulin, dolastatin 10, noscapine, hemiasterlin, and rhizoxin are discussed as tubulin polymerization inhibitors, while the taxanes and the epothilones are the major classes of tubulin polymerization promoters presented, with brief treatments of discodermolide, eleutherobin, and laulimalide. The challenges and future directions of tubulin-interactive natural products-based drug discovery programs are also discussed briefly.

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Scheme 1
Semisynthesis of paclitaxel
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References

    1. This manuscript is based in part on a lecture given at the American Association for Cancer Research Educational Program, Symposium on Natural Products in Anticancer Drug Discovery, San Diego, CA, April 12-16, 2008. A long abstract of the lecture has been published: Kingston DGI. American Association for Cancer Research 99th Annual Meeting Education Book. AACR; Philadelphia: 2008. Tubulin-Interactive Natural Products as Anticancer Agents; pp. 305–313.

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