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. 2008 Nov-Dec;8(6):143-7.
doi: 10.1111/j.1535-7511.2008.00273.x.

Effects of in utero antiepileptic drug exposure

Kimford J Meador  1
Affiliations

Effects of in utero antiepileptic drug exposure

Kimford J Meador. Epilepsy Curr. 2008 Nov-Dec.

Abstract

Recent studies demonstrate an increased teratogenic risk for valproate and a probable increased risk for phenobarbital. Carbamazepine and lamotrigine appear relatively safe; however, results are inconclusive concerning a specific risk for cleft lip/palate for both drugs as well as a dose-dependent effect for malformations associated with lamotrigine. Data regarding teratogenic risks for other antiepileptic drugs are inadequate. Additional studies are needed to delineate further the risks for all antiepileptic drugs and determine the underlying mechanisms.

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References

    1. Perucca E. Birth defects after prenatal exposure to antiepileptic drugs. Lancet Neurol. 2005;4:781–786. - PubMed
    1. Motamedi GK, Meador KJ. Antiepileptic drugs and neurodevelopment. Curr Neurol Neurosci Rep. 2006;6:341–346. - PubMed
    1. Barrett C, Richens A. Epilepsy and pregnancy: Report of an Epilepsy Research Foundation Workshop. Epilepsy Res. 2003;52:147–187. - PubMed
    1. Adab N, Kini U, Vinten J, Ayres J, Baker G, Clayton-Smith J, Coyle H, Fryer A, Gorry J, Gregg J, Mawer G, Nicolaides P, Pickering L, Tunnicliffe L, Chadwick DW. The longer term outcome of children born to mothers with epilepsy. J Neurol Neurosurg Psychiatry. 2004;75:1575–1583. - PMC - PubMed
    1. Mullers-Kuppers VM. Embryopathy during pregnancy caused by taking anticonvulsants. Acta Paedopsychiatr. 1963;30:401–405. - PubMed