Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Nov;113(6):427-38.
doi: 10.1352/2008.113:427-438.

Autism profiles of males with fragile X syndrome

Susan W Harris  1 , David Hessl, Beth Goodlin-Jones, Jessica Ferranti, Susan Bacalman, Ingrid Barbato, Flora Tassone, Paul J Hagerman, Herman Herman, Randi J Hagerman
Affiliations

Autism profiles of males with fragile X syndrome

Susan W Harris et al. Am J Ment Retard. 2008 Nov.

Abstract

Autism, which is common in individuals with fragile X syndrome, is often difficult to diagnose. We compared the diagnostic classifications of two measures for autism diagnosis, the ADOS and the ADI-R, in addition to the DSM-IV-TR in 63 males with this syndrome. Overall, 30% of the subjects met criteria for autistic disorder and 30% met criteria for PDD-NOS. The classifications on the ADOS and DSM-IV-TR were most similar, whereas the ADI-R classified subjects as autistic much more frequently. We further investigated the relationship of both FMRP and FMRI mRNA to symptoms of autism in this cohort and found no significant relationship between the measures of autism and molecular features, including FMRP, FMRI mRNA, and CGG repeat number.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Autism Classification of sample: ADI-R, ADOS, and DSM-IV-TR
Figure 2
Figure 2. ADOS Module 1
Module 1 Communication + Social Total (Comm-Soc) can range from 0 to 24. Module 1 Autism cutoff=12, autism spectrum cutoff=4. Module 1 Stereotyped Behaviors and Restricted Interests Score (RB) can range from 0 to 6 (this score, however, is not used in the algorithm used to determine the overall autism classification of the ADOS).
See this image and copyright information in PMC

References

    1. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders. Fourth Edition. American Psychiatric Association; Washington DC: 2000. Text Revision (DSM-IV-TR)
    1. Aziz M, Stathopulu E, Callias M, Taylor C, Turk J, Oostra B, et al. Clinical features of boys with fragile X premutations & intermediate alleles. American Journal of Medical Genetics. 2003;121B(1):119–127. - PubMed
    1. Bailey DB, Jr., Hatton DD, Mesibov GB, Ament N, Skinner M. Early development, temperament and functional impairment in autism and fragile X syndrome. J Autism Dev Disord. 2000;30(1):49–59. - PubMed
    1. Bailey DB, Jr., Hatton DD, Skinner M, Mesibov GB. Autistic behavior, FMR1 protein, and developmental trajectories in young males with fragile X syndrome. Journal of Autism and Developmental Disorders. 2001;31(2):165–174. - PubMed
    1. Bailey DB, Jr., Mesibov GB, Hatton DD, Clark RD, Roberts JE, Mayhew L. Autistic behavior in young boys with fragile X syndrome. Journal of Autism and Developmental Disorders. 1998;28(6):499–508. - PubMed

Publication types

MeSH terms

Substances