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Editorial
. 2009 Feb;155(2):125-7.
doi: 10.1111/j.1365-2249.2008.03864.x.

Post-mortem analysis of islet pathology in type 1 diabetes illuminates the life and death of the beta cell

J Spencer, M Peakman
Editorial

Post-mortem analysis of islet pathology in type 1 diabetes illuminates the life and death of the beta cell

J Spencer et al. Clin Exp Immunol. 2009 Feb.
No abstract available

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Figures

Fig. 1
Fig. 1
Paraffin sections of normal human pancreas stained using antibodies to (a) collagen IV and (b) endothelial antigen CD34 to highlight the peripheral boundary between the islets and the exocrine tissues (arrows) and blood vessels of the islet (arrow heads), neither of which are crossed by lymphocytes in healthy pancreas.
Fig. 2
Fig. 2
Paraffin section of normal human pancreas double-stained with a subtractive method to identify CD8+ cells (brown) and CD3+, CD8− cells (red). The most abundant T cell population in normal exocrine pancreas expresses CD8. CD8-expressing T cells are present between the epithelial cells of the acini (closed arrows) and in the connective tissue between the glands (closed arrow heads). CD8− T cells are evident in the connective tissue between lobules (open arrowheads). Additional experiments showed that the CD8+ cells in pancreas also express CD3.
See this image and copyright information in PMC

Comment on

References

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