Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Jan 13;106(2):351-2.
doi: 10.1073/pnas.0811994106. Epub 2009 Jan 7.

Trimorphic stepping stones pave the way to fungal virulence

Affiliations
Review

Trimorphic stepping stones pave the way to fungal virulence

Robert J Bastidas et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Fungal morphological transitions. (A) Yeast undergoes dimorphic transitions to pseudohyphae or hyphae controlled by different elements (X, Y). (B) A continuous transition from yeast to pseudohyphae to hyphae controlled by a dosage-dependent factor (x, X).
Fig. 2.
Fig. 2.
Evolution of fungal form and function. Mono-, di-, and trimorphic fungi are shown.

Comment on

References

    1. James TY, et al. Reconstructing the early evolution of fungi using a six-gene phylogeny. Nature. 2006;443:818–822. - PubMed
    1. Baldouf SL, Palmer JD. Animals and fungi are each other's closest relatives: Congruent evidence from multiple proteins. Proc Natl Acad Sci USA. 1993;90:11558–11562. - PMC - PubMed
    1. Wainright PO, et al. Monophyletic origins of the metazoa: An evolutionary link with fungi. Science. 1993;260:340–342. - PubMed
    1. Gimeno CJ, et al. Unipolar cell divisions in the yeast Saccharomyces cerevisiae lead to filamentous growth: regulation by starvation and RAS. Cell. 1992;68:1077–1090. - PubMed
    1. Carlisle PL, et al. Expression levels of a filament-specific transcriptional regulator are sufficient to determine Candida albicans morphology and virulence. Proc Natl Acad Sci USA. 2009;106:599–604. - PMC - PubMed