The angiotensin I converting enzyme
- PMID: 191298
Item in Clipboard
The angiotensin I converting enzyme
Fed Proc.
1977 Apr.
Abstract
The angiotensin I converting enzyme (kininase II; peptidyl dipeptidase; EC3.4.15.1) has a dual function: it converts angiotensin I to angiotensin II and it inactivates bradykinin. Lung, kidney, guinea pig plasma and testicles are among the richest sources of the enzyme. Vascular endothelial cells and bursh borders of renal proximal tubular cells contain high concentrations of the enzyme. The availability of synthetic peptide inhibitors was a great help in establishing the function of converting enzyme in normal and pathological conditions.
Similar articles
-
Metabolism of vasoactive peptides by human endothelial cells in culture. Angiotensin I converting enzyme (kininase II) and angiotensinase.J Clin Invest. 1977 Apr;59(4):684-95. doi: 10.1172/JCI108687. J Clin Invest. 1977. PMID: 191471 Free PMC article.
-
[Peptides--inhibitors of carboxycathepsin (peptidyl-dipeptidase A) and their role in clinical medicine].Vopr Med Khim. 1984 May-Jun;30(3):51-6. Vopr Med Khim. 1984. PMID: 6206649 Russian.
-
Effect of new peptide inhibitors on the ratio of angiotensin I-converting and kinin-degrading activities of dipeptidyl carboxypeptidase (angiotensin-converting enzyme).Biochemistry (Mosc). 1997 Mar;62(3):247-50. Biochemistry (Mosc). 1997. PMID: 9275297
-
Conversion of angiotensin I to angiotensin II.Am J Med. 1976 May 31;60(6):749-59. doi: 10.1016/0002-9343(76)90889-5. Am J Med. 1976. PMID: 190881 Review.
-
The emerging role of angiotensin-converting enzyme-2 in the kidney.Curr Opin Nephrol Hypertens. 2007 Mar;16(2):116-21. doi: 10.1097/MNH.0b013e3280123c0e. Curr Opin Nephrol Hypertens. 2007. PMID: 17293686 Review.
Cited by
-
The cellular basis of angiotensin converting enzyme mRNA expression in rat heart.Basic Res Cardiol. 1996;91 Suppl 2:57-63. doi: 10.1007/BF00795364. Basic Res Cardiol. 1996. PMID: 8957546
-
Evidence for participation of kinins in the antihypertensive effect of converting enzyme inhibition.Klin Wochenschr. 1981 Jan 15;59(2):69-74. doi: 10.1007/BF01477285. Klin Wochenschr. 1981. PMID: 6163004
-
Effect of converting enzyme inhibition on the renal haemodynamic responses to noradrenaline infusion in the rat.Br J Pharmacol. 1982 Mar;75(3):553-8. doi: 10.1111/j.1476-5381.1982.tb09173.x. Br J Pharmacol. 1982. PMID: 6175369 Free PMC article.
-
Response of serum angiotensin converting enzyme, plasma renin activity and plasma aldosterone to conventional dialysis in patients on chronic haemodialysis.Int Urol Nephrol. 1995;27(4):465-70. doi: 10.1007/BF02550085. Int Urol Nephrol. 1995. PMID: 8586522
-
The management of hypertension.Br J Clin Pharmacol. 1986;21 Suppl 2(Suppl 2):129S-142S. doi: 10.1111/j.1365-2125.1986.tb02862.x. Br J Clin Pharmacol. 1986. PMID: 3530297 Free PMC article. Review. No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources