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. 2009 Jan 13;53(2):176-83.
doi: 10.1016/j.jacc.2008.09.032.

Depression and cardiovascular health care costs among women with suspected myocardial ischemia: prospective results from the WISE (Women's Ischemia Syndrome Evaluation) Study

Thomas Rutledge  1 , Viola Vaccarino, B Delia Johnson, Vera Bittner, Marian B Olson, Sarah E Linke, Carol E Cornell, Wafia Eteiba, David S Sheps, Jennifer Francis, David S Krantz, C Noel Bairey Merz, Susmita Parashar, Eileen Handberg, Diane A Vido, Leslee J Shaw
Affiliations

Depression and cardiovascular health care costs among women with suspected myocardial ischemia: prospective results from the WISE (Women's Ischemia Syndrome Evaluation) Study

Thomas Rutledge et al. J Am Coll Cardiol. .

Abstract

Objectives: This study evaluated 3 novel questions in a prospective clinical cohort of women undergoing evaluation for suspected myocardial ischemia: 1) What is the relationship between depression and cardiovascular costs? 2) Does the relationship vary by definition of depression? 3) Do depression-cost relationship patterns differ among women with versus without coronary artery disease (CAD)?

Background: Comorbid depression has been linked to higher medical costs in previous studies of cardiovascular patients.

Methods: A total of 868 women presenting with suspected myocardial ischemia completed an extensive baseline examination including cardiovascular risk factor assessment and coronary angiogram. Depression was defined by: 1) current use of antidepressants; 2) a reported history of depression treatment; and 3) Beck Depression Inventory scores. Direct (hospitalizations, office visits, procedures, and medications) and indirect (out-of-pocket, lost productivity, and travel) costs were collected through 5 years of follow-up to estimate cardiovascular costs.

Results: Using the study criteria, 17% to 45% of the women studied met study depression criteria. Depressed women showed adjusted annual cardiovascular costs $1,550 to $3,300 higher than nondepressed groups (r = 0.08 to 0.12, p < 0.05). Depression-cost relationships also varied by CAD status, with stronger associations present among women without evidence of significant CAD.

Conclusions: Depression was associated with 15% to 53% increases in 5-year cardiovascular costs, and cost differences were present using 3 definitions of depression. The results reinforce the importance of assessing depression in clinical populations and support the hypothesis that improved management of depression in women with suspected myocardial ischemia could reduce medical costs.

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Conflict of interest statement

No conflicts of interest were present for the listed authors

Figures

Figure 1
Figure 1. Cardiovascular costs categorized by depression status
All depression groups differed from non-depressed women in univariate analysis (p’s<.05).
See this image and copyright information in PMC

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