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. 2009 Apr;32(4):644-6.
doi: 10.2337/dc08-1631. Epub 2009 Jan 8.

Combined measurement of fasting plasma glucose and A1C is effective for the prediction of type 2 diabetes: the Kansai Healthcare Study

Kyoko Kogawa Sato  1 , Tomoshige Hayashi, Nobuko Harita, Takeshi Yoneda, Yoshiko Nakamura, Ginji Endo, Hiroshi Kambe
Affiliations

Combined measurement of fasting plasma glucose and A1C is effective for the prediction of type 2 diabetes: the Kansai Healthcare Study

Kyoko Kogawa Sato et al. Diabetes Care. 2009 Apr.

Abstract

Objective: We prospectively assessed whether the combined measurements of fasting plasma glucose (FPG) and A1C were effective for predicting type 2 diabetes.

Research design and methods: Study participants included 6,736 nondiabetic Japanese men aged 40-55 years. Type 2 diabetes was diagnosed in those who had an FPG >or=126 mg/dl or who were being treated with an oral antidiabetic agent or insulin. The models including FPG, A1C, and both were compared using the area under the receiver operating characteristic (AUROC) curves.

Results: During the 4-year follow-up period, we confirmed 659 diabetes cases. In multivariate analysis, both FPG and A1C were independently associated with the risk of type 2 diabetes. The model including both FPG and A1C had a greater AUROC curve than that including FPG alone (0.853 vs. 0.818; P < 0.001) or A1C alone (0.853 vs. 0.771; P < 0.001).

Conclusions: The combined measurement of FPG and A1C was effective for predicting type 2 diabetes.

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References

    1. Qaseem A, Vijan S, Snow V, Cross JT, Weiss KB, Owens DK: Clinical Efficacy Assessment Subcommittee of the American College of Physicians: Glycemic control and type 2 diabetes mellitus: the optimal hemoglobin A1c targets. A guidance statement from the American College of Physicians. Ann Intern Med 147: 417– 422, 2007 - PubMed
    1. American Diabetes Association: Standards of Medical Care in Diabetes—2007 (Position Statement). Diabetes Care 30 ( Suppl. 1): S4– S41, 2007 - PubMed
    1. Sato KK, Hayashi T, Kambe H, Nakamura Y, Harita N, Endo G, Yoneda T: Walking to work is an independent predictor of incidence of type 2 diabetes in Japanese men: the Kansai Healthcare Study. Diabetes Care 30: 2296– 2298, 2007 - PubMed
    1. Sato KK, Hayashi T, Nakamura Y, Harita N, Yoneda T, Endo G, Kambe H: Liver enzymes compared with alcohol consumption in predicting the risk of type 2 diabetes: the Kansai Healthcare Study. Diabetes Care 31: 1230– 1236, 2008 - PubMed
    1. Shima K, Endo J, Oimomi M, Oshima I, Omori Y, Katayama Y, Kawai T, Kawamori R, Kanno T, Kiyose H, Nakashima K, Nagamine Y, Baba S, Hoshino T: Inter-laboratory difference in A1C measurement in Japan: a report of the committee on an inter-laboratory standardization of A1C determination, the Japan Diabetes Society. Journal of the Japan Diabetes Society 37: 855– 864, 1994

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