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. 2009 Mar;108(1-3):285-7.
doi: 10.1016/j.schres.2008.11.018. Epub 2009 Jan 8.

Prenatal infection and cavum septum pellucidum in adult schizophrenia

Alan S Brown  1 , Raymond F Deicken, Sophia Vinogradov, William S Kremen, John H Poole, Justin D Penner, Anna Kochetkova, David Kern, Catherine A Schaefer
Affiliations

Prenatal infection and cavum septum pellucidum in adult schizophrenia

Alan S Brown et al. Schizophr Res. 2009 Mar.

Abstract

Increased length of the cavum septum pellucidum (CSP) and in utero infection are each associated with increased risk of schizophrenia. Hence, we examined whether prenatal infections are related to CSP length in schizophrenia patients. In a well-characterized birth cohort, in utero infection was assessed using serologic biomarkers or physician diagnoses. Magnetic resonance images were acquired, and CSP length was quantified by a standard protocol. In utero infection was associated with increased CSP length in exposed schizophrenia cases compared to unexposed cases, suggesting that prenatal infection plays a role in a neurodevelopmental morphologic anomaly that has been related previously to schizophrenia.

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Conflict of interest statement

Conflict of Interest

None of the authors has any possible conflict of interest, financial or otherwise, related directly or indirectly to the submitted work.

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