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Comment
. 2009 Jan 9;136(1):13-4.
doi: 10.1016/j.cell.2008.12.028.

The secret life of Smad4

Jeffrey L Wrana  1
Affiliations
Free article
Comment

The secret life of Smad4

Jeffrey L Wrana. Cell. .
Free article

Abstract

Smad4 is an important mediator of signaling by TGFbeta family members that is presumed to be controlled by the phosphorylation status of its partners, the receptor-regulated R-Smads. In this issue, Dupont et al. (2009) now reveal that Smad4 itself is subject to cycles of ubiquitination and deubiquitination that regulate its interactions with the R-Smads.

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