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Comment
. 2009 Jan 9;136(1):19-21.
doi: 10.1016/j.cell.2008.12.034.

When sirtuins and NF-kappaB collide

Gioacchino Natoli  1
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Free article
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When sirtuins and NF-kappaB collide

Gioacchino Natoli. Cell. .
Free article

Abstract

Both the sirtuins and certain transcription factors of the NF-kappaB/Rel family control aging-associated changes in gene expression. Kawahara et al. (2009) now show a requirement in mice for the sirtuin SIRT6 in dampening NF-kappaB-dependent gene expression, thus unveiling a potential link between inflammation, aging, and metabolism.

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