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Case Reports
. 1991 Aug;55(1):35-8.
doi: 10.1016/0165-4608(91)90232-j.

del(15)(q11q15) associated with transformation of chronic myelomonocytic leukemia

A Provan  1 , R V Majer, A Herbert, A G Smith
Affiliations
Case Reports

del(15)(q11q15) associated with transformation of chronic myelomonocytic leukemia

A Provan et al. Cancer Genet Cytogenet. 1991 Aug.

Abstract

Nonrandom cytogenetic abnormalities have been described in a variety of human malignancies including myelodysplastic syndromes (MDS). Acquisition of new chromosomal abnormalities may herald onset of a more aggressive disease. We report a patient with chronic myelomonocytic leukemia (CMMoL) who initially had a normal karyotype, but in whom the clonal interstitial deletion of chromosome 15 (q11-q15) was coincident with development of acute myeloid leukemia (AML) one year later. To date, this chromosomal change has not been reported in CMMoL, AML, or any other human malignancy.

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