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. 2009 Feb 1;17(3):1325-38.
doi: 10.1016/j.bmc.2008.12.017. Epub 2008 Dec 24.

Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells

James Chadwick  1 , Amy E Mercer, B Kevin Park, Richard Cosstick, Paul M O'Neill
Affiliations

Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells

James Chadwick et al. Bioorg Med Chem. .

Abstract

A series of artemisinin dimers incorporating a metabolically stable C-10 carba-linkage have been prepared, several of which show remarkable in vitro antimalarial activity (as low as 30 pM) versus Plasmodium falciparum and in vitro anticancer activity in the micromolar to nanomolar range versus HL-60 cell lines.

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