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. 1991 Oct 1;51(19):5139-43.

Hypoxic fractions in xenografted human colon tumors

J T Leith  1 , G Padfield, L Faulkner, S Michelson
Affiliations
  • PMID: 1913639

Hypoxic fractions in xenografted human colon tumors

J T Leith et al. Cancer Res. .

Abstract

We investigated the percentage of radiobiologically hypoxic cells within 11 different xenografted human colon tumors using an in vivo-in vitro excision assay technique. Tumors were excised at average volumes of 750 mm3, and it was found that hypoxic fractions varied from less than 1% (clone D) to over 80% (HCT-8). The geometric mean hypoxic percentage was 10.4% (95% confidence interval, 4.9 to 22.1%). Comparison of the percentage of hypoxia results from the xenografted human colon tumors to published data from xenografted melanomas suggests that transplanted colorectal tumors as a class contain significantly less hypoxia than do the melanomas.

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