Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Aug;1(3):161-6.
doi: 10.1158/1940-6207.CAPR-08-0076.

The untapped potential of genetically engineered mouse models in chemoprevention research: opportunities and challenges

Cory Abate-Shen  1 , Powel H Brown, Nancy H Colburn, Eugene W Gerner, Jeffery E Green, Martin Lipkin, William G Nelson, David Threadgill
Affiliations
Review

The untapped potential of genetically engineered mouse models in chemoprevention research: opportunities and challenges

Cory Abate-Shen et al. Cancer Prev Res (Phila). 2008 Aug.

Abstract

The past decade has witnessed the unveiling of a powerful new generation of genetically engineered mouse (GEM) models of human cancer, which are proving to be highly effective for elucidating cancer mechanisms and interrogating novel experimental therapeutics. This new generation of GEM models are well suited for chemoprevention research, particularly for investigating progressive stages of carcinogenesis, identifying biomarkers for early detection and intervention, and preclinical assessment of novel agents or combinations of agents. Here we discuss opportunities and challenges for the application of GEM models in prevention research, as well as strategies to maximize their relevance for human cancer.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Chemoprevention: From Mouse to Man
See this image and copyright information in PMC

References

    1. Green JE, Hudson T. The promise of genetically engineered mice for cancer prevention studies. Nat Rev Cancer. 2005;5:184–198. - PubMed
    1. Van Dyke T, Jacks T. Cancer modeling in the modern era: progress and challenges. Cell. 2002;108:135–144. - PubMed
    1. DeNardo DG, Coussens LM. Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression. Breast Cancer Res. 2007;9:212. - PMC - PubMed
    1. Nelson WG, DeWeese TL, DeMarzo AM. The diet, prostate inflammation, and the development of prostate cancer. Cancer Metastasis Rev. 2002;21:3–16. - PubMed
    1. Garrett WS, Lord GM, Punit S, et al. Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell. 2007;131:33–45. - PMC - PubMed

Publication types