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Comment
. 2009 Jan;58(1):24-7.

ACE inhibitors and ARBs: one or the other--not both--for high-risk patients

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Comment

ACE inhibitors and ARBs: one or the other--not both--for high-risk patients

Shamita Misra et al. J Fam Pract. 2009 Jan.

Abstract

The combination of an ACE inhibitor and an ARB reduces proteinuria, but leads to worse renal outcomes

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Comment on

References

    1. The ONTARGET Investigators. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med. 2008;358:1547–1559.. - PubMed
    1. Yusuf S, Sleight P, Pogue J, et al. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med. 2000;342:145–153.. - PubMed
    1. Jennings DL, Kalus JS, Coleman CI, et al. Combination therapy with an ACE inhibitor and an angiotensin receptor blocker for diabetic nephropathy: a meta-analysis. Diabet Med. 2007;24:486–493.. - PubMed
    1. Mogensen CE, Neldam S, Tikkanen I, et al. Randomised controlled trial of dual blockade of renin-angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: the candesartan and lisinopril microalbuminuria (CALM) study. BMJ. 2000;321:1440–1444.. - PMC - PubMed
    1. Nakao N, Yoshimura A, Morita H, et al. Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): a randomised controlled trial. Lancet. 2003;361:117–124.. - PubMed