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Randomized Controlled Trial
. 2009;27(2):187-93.
doi: 10.1159/000190786. Epub 2009 Jan 14.

Effect of FX dialysers on systemic inflammation and quality of life in chronic haemodialysis patients

Neil Boudville  1 , Marilyn Horner, Elizabeth McEwan, Wai H Lim, David W Mudge, Hadley E Markus
Affiliations
Randomized Controlled Trial

Effect of FX dialysers on systemic inflammation and quality of life in chronic haemodialysis patients

Neil Boudville et al. Blood Purif. 2009.

Abstract

Background: The FX class of haemodialysers features a new class of high-flux polysulfone membrane which has been suggested to induce less inflammation.

Methods: This was a randomized, cross-over study performed on 33 haemodialysis patients. Patients were randomized to FX60 or HF80 dialysers for 3 months and then changed to the other dialyser. Interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP) were measured at baseline, and every 3 months. The Kidney Disease Quality of Life Short Form was also administered.

Results: The mean of the difference in the IL-6 level between dialysers was 1.4 +/- 8.0 pg/ml (95% CI -1.8, 4.5 pg/ml). There was no significant difference in TNF-alpha (95% CI -0.35, 0.18 pg/ml) or CRP levels (95% CI -2.67, 6.20 mg/l). The quality of social interaction and role limitations caused by physical health problems were significantly higher with the FX60, p = 0.04 and 0.047, respectively.

Conclusions: The FX dialysers do not result in a significant difference in the level of systemic inflammation compared to the HF80.

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