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. 2009 Jan 16;74(2):932-4.
doi: 10.1021/jo8021204.

An expeditious synthesis of bruguierol A

Francisco J Fañanás  1 , Amadeo Fernández, Deniz Cevic, Félix Rodríguez
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An expeditious synthesis of bruguierol A

Francisco J Fañanás et al. J Org Chem. .

Abstract

A very simple strategy for the construction of 2,3-benzofused 8-oxabicyclo[3.2.1]octane derivatives is reported. This new process is based on a platinum-catalyzed tandem intramolecular hydroalkoxylation-hydroarylation reaction of aryl-substituted pentynol derivatives. This reaction has been applied in the key step of the total synthesis of bruguierol A, allowing the synthesis of this natural product in a very straightforward manner.

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