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Review
. 2009 Feb;37(Pt 1):195-9.
doi: 10.1042/BST0370195.

The ESCRT machinery: new functions in viral and cellular biology

Jeremy G Carlton  1 , Juan Martin-Serrano
Affiliations
Review

The ESCRT machinery: new functions in viral and cellular biology

Jeremy G Carlton et al. Biochem Soc Trans. 2009 Feb.

Abstract

The ESCRT (endosomal sorting complex required for transport) machinery consists of a number of cytosolic proteins that make up three functional subcomplexes: ESCRT-I, ESCRT-II and ESCRT-III. These proteins function in multivesicular body formation and cell division and are co-opted by enveloped retroviruses to facilitate viral egress. Analysis of these functions may help illuminate conserved mechanisms of ESCRT function.

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