Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2009 Feb;64(2):147-51.
doi: 10.1111/j.1365-2044.2008.05732.x.

Ondansetron has similar clinical efficacy against both nausea and vomiting

R M Jokela  1 , O S Cakmakkaya, O Danzeisen, K T Korttila, P Kranke, A Malhotra, A Paura, O C Radke, D I Sessler, A Soikkeli, N Roewer, C C Apfel
Affiliations
Randomized Controlled Trial

Ondansetron has similar clinical efficacy against both nausea and vomiting

R M Jokela et al. Anaesthesia. 2009 Feb.

Abstract

Ondansetron is widely believed to prevent postoperative vomiting more effectively than nausea. We analysed data from 5161 patients undergoing general anaesthesia who were randomly stratified to receive a combination of six interventions, one of which was 4 mg ondansetron vs placebo. For the purpose of this study a 20% difference in the relative risks for the two outcomes was considered clinically relevant. Nausea was reduced from 38% (969/2585) in the control to 28% (715/2576) in the ondansetron group, corresponding to a relative risk of 0.74, or a relative risk reduction of 26%. Vomiting was reduced from 17% (441/2585) to 11% (293/2576), corresponding to a relative risk of 0.67, or a relative risk reduction of 33%. The relative risks of 0.67 and 0.74 were clinically similar and the difference between them did not reach statistical significance. We thus conclude that ondansetron prevents postoperative nausea and postoperative vomiting equally well.

PubMed Disclaimer

Publication types