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. 2009 Mar 1;385(1):5-10.
doi: 10.1016/j.virol.2008.12.016. Epub 2009 Jan 14.

Genetic analysis of canine parvovirus type 2c

Nicola Decaro  1 , Costantina Desario, Antonio Parisi, Vito Martella, Alessio Lorusso, Angela Miccolupo, Viviana Mari, Maria Loredana Colaianni, Alessandra Cavalli, Livia Di Trani, Canio Buonavoglia
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Free article

Genetic analysis of canine parvovirus type 2c

Nicola Decaro et al. Virology. .
Free article

Abstract

The sequence of the full-length gene encoding for the main capsid protein VP2 of 58 canine parvovirus (CPV) type 2c strains, along with recent CPV-2a/2b strains, was determined and analysed in comparison with reference CPV isolates. The CPV-2c strains displayed a low genetic variability and shared amino acid changes already detected in recent CPV-2a/2b isolates, with a phylogenetic clustering accounting for their geographical distribution. Analysis of the selection pressure driving CPV evolution confirmed that the VP2 gene is under purifying selection. The emergence and global spread of the new CPV variant provides an interesting model to better understand virus evolution.

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