Relationship of stimulated saliva 17beta-estradiol and oral dryness feeling in menopause

Abstract

Objectives: The aim of this study was to compare stimulated whole saliva 17beta-estradiol of menopausal women with/without oral dryness (OD) feeling, and evaluate the relationship between saliva 17beta-estradiol and severity of OD feeling.

Methods: A case-control study was carried out in 76 selected menopausal women aged 41-77 years with or without OD feeling (38 as case and 38 as control) conducted at the Clinic of Oral Medicine, Tehran university of medical sciences. Paraffin-stimulated saliva samples were obtained by expectoration. Xerostomia inventory (XI) score was used as an index of OD feeling severity. The saliva 17beta-estradiol concentration was measured by ELISA. Statistical analysis of Student's t-test and Spearman correlation was used.

Results: No significant difference was found in stimulated whole saliva flow rate between the two groups, but the mean concentration and output of saliva 17beta-estradiol were significantly lower in case than control. There was significant negative correlation between XI score and stimulated whole saliva concentration (r=-0.391, P=0.004) and output (r=-0.302, P=0.002) of 17beta-estradiol in menopausal women.

Conclusions: It seems that there is a negative correlation between OD feeling severity and stimulated whole saliva 17beta-estradiol in menopausal women.