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Review
. 2009 Apr;109(4):1537-48.
doi: 10.1021/cr800414e.

The multiple layers of ubiquitin-dependent cell cycle control

Katherine Wickliffe  1 , Adam Williamson, Lingyan Jin, Michael Rape
Affiliations
Review

The multiple layers of ubiquitin-dependent cell cycle control

Katherine Wickliffe et al. Chem Rev. 2009 Apr.
No abstract available

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Figures

Figure 1
Figure 1. Enzymatic players in ubiquitin dependent cell cycle control
A. Schematic overview over the enzymatic cascade catalyzing ubiquitination. B. Examples of enzymes at the different steps of ubiquitination that have roles in ubiquitin-dependent cell cycle control.
Figure 2
Figure 2. Different ubiquitin modifications have distinct functions in cell cycle control
Substrates can be modified with a single ubiquitin (monoubiquitination) or with ubiquitin chains (multiubiquitination). Ubiquitin chains differ in structure and function, depending on what lysine of ubiquitin is used for chain formation. Examples for different modifications and their substrates in cell cycle control are shown on the right.
Figure 3
Figure 3. Examples of modified substrates in ubiquitin-dependent cell cycle control
Left panel: Examples of ubiquitinated proteins, which are not degraded upon their modification. In parentheses, the function of the relevant modification in cell cycle control is noted. Right panel: Examples of proteins that are degraded after being ubiquitinated at different times in the cell cycle. In parenthesis, the relevant ubiquitin ligases are noted.
See this image and copyright information in PMC

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