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Review
. 2009 Jan 15;69(2):393-5.
doi: 10.1158/0008-5472.CAN-08-2749.

MicroRNA silencing in primates: towards development of novel therapeutics

Andreas Petri  1 , Morten Lindow, Sakari Kauppinen
Affiliations
Review

MicroRNA silencing in primates: towards development of novel therapeutics

Andreas Petri et al. Cancer Res. .

Abstract

MicroRNAs (miRNA) comprise an abundant class of small noncoding RNAs that act as important posttranscriptional regulators of gene expression. Accumulating evidence showing that aberrantly expressed miRNAs play important roles in human cancers underscores them as potential targets for therapeutic intervention. Recent reports on efficient miRNA silencing in rodents and nonhuman primates using high-affinity targeting by chemically modified antisense oligonucleotides highlight the utility of such compounds in the development of miRNA-based cancer therapeutics.

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