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. 1977 Feb;3(1):37-44.

The involvement of prostaglandin endoperoxide formation in the elevation of cyclic GMP levels during platelet aggregation

D B Glass, J M Gerrard, D Townsend, D W Carr, J G White, N D Goldberg
  • PMID: 191476

The involvement of prostaglandin endoperoxide formation in the elevation of cyclic GMP levels during platelet aggregation

D B Glass et al. J Cyclic Nucleotide Res. 1977 Feb.

Abstract

Arachidonic acid- or collagen-induced aggregation was accompanied by a progressive elevation in the level of cyclic GMP in washed human platelets with no significant alteration in the concentration of cyclic AMP. The extent of the increase in cyclic GMP was proportional to the concentration of arachidonic acid added. Enhanced accumulation of cyclic GMP produced by arachidonic or collagen was prevented by prior exposure of platelets to aspirin or indomethacin. Prostaglandin endoperoxide G2 caused platelet aggregation and an increase in cyclic GMP concentration; neither event was blocked by prostaglandin synthesis inhibitors. These results indicate that the generation of prostaglandin endoperoxides is a step in the sequence of events in platelet aggregation leading to the enhanced accumulation of cyclic GMP.

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